Methotrexate use in men attempting to father a child
What is it?
Methotrexate (Maxtrex®, Metoject®) is used to treat a number of auto-immune illnesses such as Crohn’s disease, rheumatoid arthritis and psoriasis, and in the treatment of certain types of cancer.
Should methotrexate be used by male partner while a couple is attempting to conceive?
Because of the way that methotrexate works, there are theoretical concerns that it could damage sperm, and potentially affect the development of a baby conceived while the father is using it.
The babies of around 360 men who were using methotrexate around the time of conception have been studied and while there is currently no suggestion of any links with miscarriage, stillbirth, birth defects, low infant birth weight, or preterm birth, ongoing research is required to confirm that there are no ill effects.
As a precaution, the manufacturers of methotrexate usually advise that couples where the male partner takes methotrexate use contraception and wait at least three months after stopping treatment before attempting to conceive. This is because it takes approximately three months for a sperm to form.
In practice, because there is no clear evidence of ill effects, if a couple is planning a pregnancy and the man’s medical condition is well-controlled with methotrexate, a specialist will be able help them weigh up the potential risks and benefits of continuing the medication so that informed decisions can be made about treatment. Do not make any change to your medication without first talking to your doctor.
Will the baby need extra monitoring during pregnancy?
Most women will be offered a scan at around 20 weeks of pregnancy to look for birth defects as part of their routine antenatal care. No additional monitoring of pregnancies conceived while the father was using methotrexate are required.
Who can I talk to if I have questions?
If you have any questions regarding the information in this leaflet please discuss them with your health care provider. They can access more detailed medical and scientific information from www.uktis.org.