Imatinib
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Imatinib used in early pregnancy might cause a baby to have birth defects but stopping imatinib could cause cancer to come back. A doctor will advise on the risks and benefits for each woman.
What is it?
Imatinib (Glivec®) is used to treat some types of leukaemia and other cancers.
Benefits
What are the benefits of taking imatinib in pregnancy?
Imatinib can be an effective treatment for leukaemia and other types of cancer. Continued imatinib treatment could help to prevent cancer from returning.
Risks
Are there any risks of taking imatinib in pregnancy?
Possibly. Around 250 women taking imatinib in early pregnancy have been studied. While most of their babies were healthy, a small number had a similar pattern of birth defects. This suggests that in rare cases, imatinib might affect the unborn baby’s development.
Alternatives
Are there any alternatives to taking imatinib in pregnancy?
Possibly. Other drugs that are safer in pregnancy can be used to treat some cancers but may not work as well as imatinib. Occasionally, treatment can be stopped while trying to conceive and during pregnancy. Your doctor will talk to you about the risks and benefits of imatinib or other cancer treatments, and whether stopping treatment might be an option.
No treatment
What if I prefer not to take medicines in pregnancy?
Cancer treatment may need to be continued in pregnancy to ensure that you and your baby remain well. Your doctor will only prescribe medicines when necessary and will be happy to talk to you if you have any concerns.
Will I or my baby need extra monitoring?
As part of routine antenatal care in the UK, all women are invited for a very detailed scan at around 20 weeks of pregnancy to check the baby’s development. Because imatinib might be linked to birth defects, you might be offered this scan at a slightly earlier stage of pregnancy. Extra checks of your baby’s growth may also be offered, particularly in later pregnancy.
Are there any risks to my baby if the father has used imatinib?
We do not expect any increased risk to the baby if the father took imatinib before or around the time you became pregnant.
Who can I talk to if I have questions?
If you have any questions regarding the information in this leaflet, please discuss them with your health care provider. They can access more detailed medical and scientific information from www.uktis.org.