Quetiapine

Date: September 2024, Version 5

Quick take

Quetiapine can be used in pregnancy if recommended by a specialist.

What is it?

Quetiapine (Atrolak®, Biquelle®, Brancico®, Mintreleq®, Seroquel®, Sondate®, Zaluron®) is used to treat schizophrenia, bipolar disorder, and depression.

Benefits

What are the benefits of taking quetiapine in pregnancy?

Quetiapine can prevent relapse of serious mental health conditions. Its use can help a woman remain well during pregnancy and while looking after her baby.

Risks

Are there any risks of taking quetiapine during pregnancy?

Quetiapine use in pregnancy has been well-studied and it is not known to harm the baby.

Quetiapine can increase blood sugar levels and cause weight gain. In theory, use in pregnancy could increase the chance of gestational diabetes and lead to the baby growing faster than expected. Your baby’s growth might therefore be more closely monitored, and later in pregnancy you may be offered a test to check for gestational diabetes (‘glucose tolerance test’).

Quetiapine used around the time of delivery can cause the newborn baby to have withdrawal symptoms such as jitteriness and problems with feeding and sleeping. A hospital delivery will be recommended so that your baby can be assessed after birth and supported as necessary until these symptoms pass.

Alternatives

Are there any alternatives to taking quetiapine in pregnancy?

Possibly. A mental health specialist will be able to advise whether quetiapine is still the best treatment during pregnancy depending on your specific circumstances.

No treatment

What if I prefer not to take medicines during pregnancy?

Quetiapine use may be advised in pregnancy to prevent relapse of a potentially serious mental health condition. If you are advised to continue quetiapine in pregnancy, you can discuss the risks and benefits with your specialist.

Will my baby need extra monitoring?

Women in the UK will be offered a very detailed scan at around 20 weeks of pregnancy as part of routine antenatal care. Taking quetiapine in pregnancy would not normally require extra monitoring for birth defects. Your baby’s growth will be more closely monitored in later pregnancy as quetiapine use might be linked to increased birth weight.

If you have taken quetiapine around the time of delivery your baby may require extra monitoring after birth because of the possible risk of neonatal withdrawal.

Are there any risks to my baby if the father has taken quetiapine?

We do not expect any increased risk to your baby if the father takes quetiapine.

Who can I talk to if I have questions?

If you have any questions regarding the information in this leaflet, please discuss them with your health care provider. They can access more detailed medical and scientific information from www.uktis.org.

How can I help to improve drug safety information for pregnant women in the future?

Our online reporting system (MyBump Portal) allows women who are currently pregnant to create a secure record of their pregnancy, collected through a series of questionnaires. You will be asked to enter information about your health, whether or not you take any medicines, your pregnancy outcome and your child's development. You can update your details at any time during pregnancy or afterwards. This information will help us better understand how medicines affect the health of pregnant women and their babies. Please visit the MyBump Portal to register.

General information
Sadly, miscarriage and birth defects can occur in any pregnancy.

Miscarriage occurs in about 1 in every 5 pregnancies, and 1 in every 40 babies are born with a birth defect. This is called the ‘background risk’ and happens whether medication is taken or not.

Most medicines cross the placenta and reach the baby. For many medications this is not a problem. However, some medicines can affect a baby’s growth and development.

If you take regular medication and are planning to conceive, you should discuss whether your medicine is safe to continue with your doctor/health care team before becoming pregnant. If you have an unplanned pregnancy while taking a medicine, you should tell your doctor as soon as possible.

If a new medicine is suggested for you during pregnancy, please make sure that the person prescribing it knows that you are pregnant. If you have any concerns about a medicine, you can check with your doctor, midwife or pharmacist.

Our Bumps information leaflets provide information about the effects of medicines in pregnancy so that you can decide, together with your healthcare provider, what is best for you and your baby.