Studies & surveillance

Studies

In addition to the information UKTIS collects on a daily basis from healthcare professional enquiries for the purpose of surveillance, UKTIS also conduct and participate in a number of more specific research projects.

UKTIS are currently involved in:

  • International ‘TIS’ studies - We are collaborating with teratology information services (‘TIS’) around the world to study the effects of a variety of drugs used in pregnancy.
  • Systematic review and economic modelling of the relative clinical- and cost-effectiveness of interventions for hyperemesis gravidarum (NIHR funded).
  • Neurodevelopment of Babies Born to Mothers with Epilepsy (NaME) Study

Take part
We are not currently recruiting for studies.
 

Surveillance
We are aiming to improve the information we collect by giving women the opportunity to provide information directly to UKTIS. You are now able to do this by creating your own bumps pregnancy record.

Scientific reports and publications:

2016

Winterfeld U, Merlob P, Baud D, Rousson V, Panchaud A, Rothuizen LE, Bernard N, Vial T, Yates LM, Pistelli A, Ellfolk M, Eleftheriou G, de Vries LC, Jonville-Bera AP, Kadioglu M, Biollaz J, Buclin T. Pregnancy outcome following maternal exposure to pregabalin may call for concern. Neurology. 2016 Jun 14;86(24):2251-7.

2015

Weber-SchoendorferC, Oppermann M, Wacker E, Bernard N; network of French pharmacovigilance centres, Beghin D, Cuppers-Maarschalkerweerd B, Richardson JL, Rothuizen LE, Pistelli A, Malm H, Eleftheriou G, Kennedy D, KadiogluDuman M, Meister R, Schaefer C.Pregnancy outcome after TNF-α inhibitor therapy during the first trimester: a prospective multicentre cohort study. Br J ClinPharmacol. 2015; Mar 25.

Winterfeld U, Klinger G, Panchaud A, Stephens S, Arnon J, Malm H, Te Winkel B, Clementi M, Pistelli A, Maňáková E, Eleftheriou G, Merlob P, Kaplan YC, Buclin T, Rothuizen LE. Pregnancy Outcome Following Maternal Exposure to Mirtazapine: A Multicenter, Prospective Study.J Clin Psychopharmacol. 2015; Mar 31.  

2014

Dunstan H, Mill A, Stephens S, Yates L, Thomas S. Pregnancy outcome following maternal use of zanamivir or oseltamivir during the 2009 influenza A/H1N1 pandemic: a national prospective surveillance study. BJOG 2014; Mar 7. 

2013

Winterfeld U, Allignol A, Panchaud A, Rothuizen LE, Merlob P, Cuppers-Maarschalkerweerd B, Vial T, Stephens S, Clementi M, De Santis M, Pistelli A, Berlin M, Eleftheriou G, Manáková E, Buclin T. Pregnancy outcome following maternal exposure to statins: a multicentre prospective study. BJOG 2013; 120: 463–71.

Jones D, Stephens S, Yates LM, Thomas SHL. Prospective outcomes following acute exposure to carbamate insecticides in pregnancy. Clinical Toxicology 2013; 51:p355.

Fujii H, Goel A, Bernard N, Pistelli A, Yates LM, Stephens S, Han JY, Matsi D, Edwell F, Finarson TR, Koren G, Einarson A. Pregnancy outcomes following gabapentin use: Results of a prospective comparative cohort study, Neurology. 2013 April 23;80(17):1565-1570.

Richardson JL, Jones D, Dunstan HJ, Maitra S, Stephens S, Yates LM, Thomas SH. Gestational exposure to varenicline. Reproductive Toxicology, 2013; 37:p85.

2012

Hoeltzenbein M, Elefant E, Vial T, Finkel-Pekarsky V, Stephens S, Clementi M, Allignol A, Weber-Schoendorfer C, Schaefer C. Teratogenicity of mycophenolate confirmed in a prospective study of the European Network of Teratology Information Services. Am J Med Genet A. 2012 Mar;158A(3):588-96.

Einarson A, Smart K, Vial T, Diav-Citrin O, Yates L, Stephens S, Pistelli A, Kennedy D, Taylor T, Panchaud A, Malm H, Koren G, Einarson TR. Rates of major malformations in infants following exposure to duloxetine during pregnancy: a preliminary report. J Clin Psychiatr 2012; 73: 1471.

Thomas SHL, Yates LM. Prescribing without evidence – pregnancy. Br J Clin Pharmacol. 2012; 74: 691–7.

Yates LM, Thomas SHL. Prescribing medicines in pregnancy. Medicine 2012; 40: 386–90.

Jones D, Stephens S, Yates L, Dunstan H, Richardson JL, Greenall A, Thomas SHL. Fetal outcomes following fentanyl exposure in pregnancy. Clin Toxicol 2012; 50: 328.

Jones D, Stephens S, Yates L, Dunstan H, Richardson JL, Greenall A, Thomas SHL. Fetal outcomes following dosulepin overdose in pregnancy, Clin Toxicol 2012; 50: 327–8.

2011

Stephens S, Adams S, Richardson JL, Yates L, Thomas SHL. Outcome of pregnancy after first trimester exposure to venlafaxine. Birth Defects Research Part A: Clinical and Molecular Teratology. 2011; 91(5): 414.

Russell P, Yates L, Grant E, Golightly P. “Drugs in Pregnancy and Lactation” in Walker RS, Whitlesea C. Clinical Pharmacy & Therapeutics, 5th Edition, Churchill Livingstone 2011, Page 739-752.

2010

Yates L, Pierce M, Stephens S, Mill AC, Spark P, Kurinczuk JJ, Valappil M, Brocklehurst P, Thomas SH, Knight M. Influenza A/H1N1v in pregnancy: an investigation of the characteristics and management of affected women and the relationship to pregnancy outcomes for mother and infant. Health Technology Assessment. 2010; 14(34):109-82.

Jones D, Stephens S, Richardson JL, Yates L, Thomas SHL. The fetal effects of ibuprofen overdose in the third trimester of pregnancy and the risk of premature closure of the ductus arteriosus. Clinical Toxicology. 2010; 48 (3): 240-318.

Richardson J.L, Stephens S, Jones D, Yates L. Fetal effects of diazepam overdose during pregnancy. Clinical Toxicology. 2010; 48 (3): 281.

Stephens S, Yates L, Chincholkar V, Thomas SHL. Outcome of pregnancy after maternal exposure to mifepristone. Birth Defects Research Part A: Clinical and Molecular Teratology. 2010; 88 (5): 433.

2009

Stephens S, Wilson G. Principles in pregnant women: guide to general principles. Prescriber. 2009; 20 (23/24): 43-46.

Stephens S, Wilson G, Jones D, Thomas SHL. Preliminary data on the use of cannabis in pregnancy. Reproductive Toxicology. 2009; 28 (2): 117-284.

Wilson G, Stephens S, Jones D, Thomas SHL. Preliminary data on the use of hepatitis A and B vaccines during pregnancy. Reproductive Toxicology. 2009; 28 (2): 117-284.

Wilson G, Jones D, Stephens S, Bradley S, McElhatton P, Thomas SHL. Preliminary data on exposure to trichloroethylene during pregnancy. Clinical Toxicology. 2009; 47 (5): 436-510.

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